| 11 | | - JP: Present bio plan |
| 12 | | - Actions: |
| 13 | | - **EM**: Write up a biology plan |
| 14 | | - Decide whether to use Marie's lab and whether to stick with HeLa |
| 15 | | - **EM, MB, JP, RA**: Meet to finalise details |
| 16 | | - **Unassigned**: Obtain an inverted microscope |
| | 13 | - No Update but things discussed: |
| | 14 | - Short-term plan is probably use Marie's lab as it has the microscope, etc., but there is a preference to shift to doing everything at SCAPA. |
| | 15 | - Monitoring for the incubator, Robbie can do remote monitoring for the incubator using a Raspberry Pi, etc. |
| | 16 | - Would be useful to find the hard limit that cells can survive vertically |
| | 17 | |
| | 18 | Something has been a problem with burning mirrors that was there before with Ross |
| 20 | | - Josie to present the latest BO results on finding the optimal beamline |
| | 22 | - Josie presented the latest BO results on finding the optimal beamline |
| | 23 | - [raw-attachment:PoPLaR_update_05March26.pdf Slides] |
| | 24 | - Ran several optimisations, all using a laser-driven energy spectrum: |
| | 25 | - 2 Quad (Varying positions for transmission) |
| | 26 | - 2 Quad (Varying positions for uniformity) |
| | 27 | - 2 Quad and 4 Dipoles (Varying positions and varying dipole length and strength as a group for transmission) |
| | 28 | - Any Quad Combination (Varying number and position of quads for transmission |
| | 29 | - Generally, best results appear to have the beamline elements as close as possible to the source and have the cells as close as possible too. |
| | 30 | - To get a more useful optimisation need to specify a beam energy |
| | 31 | - Talk to Robbie about the energy spectra graph and its stability |
| | 32 | - Talk to the bio team about what energies we should be avoiding (Simulate LET for a range of energies in the cells?) |
| | 34 | - Deliver a 2.0 ± 0.4Gy beam with a lateral dose variation of 7% and centred on 8MeV |
| | 35 | - The average uncertainty on their overall dose delivered was 12% |
| | 36 | - Beamline consists of a laser-driven source, quad doublet, kapton scattering foil, dipole magnet, mouse ear, RCF and scintillator |
| | 37 | - Laser-driven source ran at 7J over 60fs, so lower power than SCAPA, and onto a 13um Kapton target (same as SCAPA). |
| | 38 | - The laser was 50um from its optimal focal length to achieve a better shot-to-shot variation. This helped reduce it from 17% to 5% |
| | 39 | - Quads are a 250 T/m with 5mm bore radius and 67T/m with 15mm bore radius |
| | 40 | - Kapton scattering foil is 25um and is placed there to smooth the beam and remove heavier ions |
| | 41 | - Dipole magnet of 264mT and 95mm in length removes x-rays, gamma-rays and electrons |
| | 42 | - 25um Kapton exit window |
| | 43 | - The mouse ear is ~300um so it allows 8MeV protons to pass through and reach RCF and a scintillator passed that |
| | 44 | - Other diagnostics are integrating current transformers |
| | 45 | - Would be worth investigating in combination with sci-fi arrays for instantaneous dose measurements |
| | 46 | - They delivered a shot every 20s, so they investigated instantaneous FLASH rather than overall FLASH |
| | 47 | - Josie will simulate the beam to get a better understanding |
| | 48 | - LhARA knows someone at BELLA, so she is the person to ask if any information is missing |
