LhARA radiobiology; meeting: 19Mar26; 14:00 GMT

ZOOM: ​https://imperial-ac-uk.zoom.us/j/98220889714?pwd=SM90vOF7BKSXoU3mD9q7OwBQo4IVB3.1

Meeting Agenda

1. BioPrep

2. Improving the Beamline

3. In-Beam Diagnostic

4. SCAPA Beamline

5. DoNM
   • 16th Apr 14:00

6. AoB

Summary of actions required

In-Beam Diagnostics

• RW, CD: Study correlation between laser diagnostics and mean dose
• CD, TP: Refine evaluations of LET in the cells with the RCF in front
• CD: Predict the cell dish dose from the RCF in front of it
• Initial measurements of sci-fi arrays
• Provide plan for Master's students who will count photons from UV source for sci-fi arrays
• PH: Investigate how to get the light out of the vacuum chamber
• Unassigned: Investigate how a phosphor sheet could be incorporated into the design of the cell dish
• Unassigned: Acquire a glass sheet

Bio Next Steps

• EM: Write up a biology plan
  • Decide whether to use Marie's lab and whether to stick with HeLa
• EM, MB, JP, RA: Meet to finalise details
• Unassigned: Obtain an inverted microscope
• Unassigned: Obtain multi-chamber haemocytometers (Might be able to use Birmingham's)
• Unassigned: Run controls to examine how long the cells can survive vertically

Improve the spatial variation

• Decide the energy we should be optimising for
  • RW: Examine energy spectra variation
  • Find LET for different energies in the cell dish

Other Beamlines

• JMcG: Simulate BELLA
• JMcG: Talk to ELI people and simulate ELI
• Build a bid towards ELI

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